How big of a population is needed for Interstellar Travel? Depending on the nature of the mission, that answer will vary. In a 100 year journey, several generations will be needed. If the journey is intended to establish a colony of some sort, enough people will be necessary to establish a viable population with a broad enough genetic mix to ensure inbreeding doesn't occur on any dangerous level.
Some estimates are 100 minimum to ensure diversity. 1000 would be better. However, these are low numbers and possibly more should be figured for maximum safety. Other factors beyond just pure genetics is important, including number of workers to maintain the environment and pilot the ship, and other non maintaining roles such as education and military/police considerations.
Great conversation about Population diversity
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